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Changes of genuine Cow-Pox
On the fourth day, or sooner, from the time of the operation, a small speck of inflammation is to be perceived, which, on the fifth day is a pimple, surrounded by a circle of inflammation. On the sixth this pim-- ple changes to a vesicle containing a thin fluid.
On the seventh this vesicle is more perfect, its margin forming a regular circle; it is also a little flattened on the top, the centre of which is of a dark color. On the eighth or ninth day slight chills, flushes of heat, etc., are sometimes felt, accompanied by swelling of the pustule and pains shoot-